I set up a Kill-a-Watt to my computer and calculated with 2200 khash/s, I was using 140 watts (monitors off). According to the calculator, I should produce a block every 14 days, 2 hours, 3 minutes, or every 338.05 hours. It would cost me 47.327 Kwh to produce a block, at 12 cents per Kwh, thats $5.68 per block, a net loser.
What is interesting is the reports of the people producing 25,000 khash/sec with their video cards in the CUDA thread. If they are using less than 1000 watts (and should be), it would be profitable again to produce, electricity wise.
Difficulty level 1000 by year end.